Hemodynamic Effects of Intravenous Enoximone in Moderately Severe Congestive Heart Failure.
10.4070/kcj.1995.25.3.684
- Author:
Jeong Hyun KIM
;
Jae Ung LEE
;
Kyung Soo KIM
;
Heon Kil LIM
;
Bang Hun LEE
;
Chung Kyun LEE
- Publication Type:Clinical Trial ; Original Article
- Keywords:
Enoximone;
Congestive heart failure
- MeSH:
Alcoholics;
Blood Pressure;
Capillaries;
Cardiac Output;
Cardiomyopathy, Dilated;
Cardiomyopathy, Restrictive;
Catheters;
Chemistry;
Electrocardiography, Ambulatory;
Enoximone*;
Estrogens, Conjugated (USP)*;
Female;
Heart Failure*;
Heart Rate;
Heart Valve Diseases;
Hematology;
Hemodynamics*;
Humans;
Male;
Pulmonary Wedge Pressure;
Radionuclide Ventriculography;
Stroke Volume;
Tachycardia;
Thermodilution;
Vascular Resistance
- From:Korean Circulation Journal
1995;25(3):684-690
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This clinical trial was performed to evaluate the hemodynamic and side effects of enoximone, a newly developed phosphodiesterase inhibitor, in moderately severe congestive heart failure in Korean population and to base the development of long acting oral preparations in the future. METHODS: Principal admission criteria for this trial were a left ventricular ejection fraction of less than 45% by radionuclide ventriculography, NYHA functional class II or III and a documented congestive cardiomyopathy. Exclusion criteria were restrictive cardiomyopathy, valvular heart disease, multisystemic lillness and uncontrolled ventricular tachyarrhythmia. The hemodynamic measurements were made by using the thermodilution Swan-Ganz catheter and radial arterial canulation. Enoximone was administered(continuous infusion) for 24 hours after initial bolus. The hemodynamic parameters to be observed were blood pressure, heart rate, cardiac output, pulmonary capillary wedge pressure, systemic and pulmonary vascular resistance. The clinical reponse, hematology, blood chemistry, and Holter monitoring were checked before and after enoximone trial. RESULTS: The following results are obtained. 1) The included patients were 15 females, 24 males, total 39 patients and mean age of 55.3 years old(28-70 years old). 2) The causes of congestive cardiomyopathy were idiopathic 35(89.9%), hypertensive 3(7.7%), and alcoholic 1(2.6%). 3) The mean ejection fraction measured by radionuclide left ventriculography were 28. 6%. 4) THe cardiac output was significantly increased(50%), and pulmonary capillary wedge pressure(38%), systemic vascular resistance(34%), pulmonary vascular resistance(27%) were significantly decreased during enoximone infusion. 5) NYHA Functional Class was improved by 1 step with enoximone. 6) There were no significant changes in hematology, blood chemistry, and Holter monitoring with enoximone. CONCLUSION: From the above results, the short term intravenous enoximone was very effective in moderately severe congestive heart failure in congestive cardiomyopathy without major adverse effects in Korean.
