Functional Disabilities Evaluated using World Health Organization Disability Assessment Schedule 2.0 in Patients with Chronic Schizophrenia and Its Related Factors
10.4306/jknpa.2019.58.1.47
- Author:
Kyeongwoo PARK
1
;
Dong Kyun LEE
;
Hyeongrae LEE
;
Chul Eung KIM
;
Seunghyong RYU
Author Information
1. Department of Mental Health Research, National Center for Mental Health, Seoul, Korea. seunghyongryu@gmail.com
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Disability evaluation;
Psychopathology
- MeSH:
Affective Symptoms;
Appointments and Schedules;
Brief Psychiatric Rating Scale;
Cognition;
Disability Evaluation;
Global Health;
Healthy Volunteers;
Humans;
Psychopathology;
Schizophrenia;
Social Participation;
World Health Organization
- From:Journal of Korean Neuropsychiatric Association
2019;58(1):47-54
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study examined the functional disabilities of patients with chronic schizophrenia using WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) and its related factors. METHODS: The subjects consisted of 86 patients with schizophrenia with more than 10 years' duration of illness and 40 healthy volunteers. The functional disabilities and psychopathology were evaluated using the WHODAS 2.0 and 18-items Brief Psychiatric Rating Scale (BPRS-18), respectively. This study analyzed the six sub-domains ('cognition', 'mobility', 'self-care', 'getting along', 'life activities', and 'participation') of WHODAS 2.0 and the four sub-scales ('positive symptoms', 'negative symptoms', 'affect', and 'resistance') of BPRS-18. RESULTS: Patients with chronic schizophrenia experienced severe functional disabilities across all six sub-domains of WHODAS 2.0 compared to healthy people. Hierarchical regression showed that 'negative symptoms' explained the disabilities in the WHODAS 2.0 sub-domains of 'cognition' (p<0.05), 'self-care' (p<0.05), 'getting along' (p<0.01), and 'life activities' (p<0.05). 'Positive symptoms' and 'affect' explained the disabilities in 'cognition' (p<0.01 and p<0.05, respectively) and 'participation' (p<0.05 and p<0.01, respectively). 'Resistance' was found to be a predictor of 'getting along' disabilities (p<0.01). CONCLUSION: Negative symptoms mainly accounted for the multiple domains of functional disabilities in the WHODAS 2.0 but residual positive and affective symptoms could also deteriorate the cognition and social participation of patients with chronic schizophrenia.
