Metabolic Syndrome Severity Score in Korean Adults: Analysis of the 2010–2015 Korea National Health and Nutrition Examination Survey
- Author:
Ji Hye HUH
1
;
Jun Hyeok LEE
;
Jin Sil MOON
;
Ki Chul SUNG
;
Jang Young KIM
;
Dae Ryong KANG
Author Information
- Publication Type:Original Article
- Keywords: Metabolic Syndrome; Epidemiology; Obesity; Insulin Resistance
- MeSH: Adult; Blood Pressure; Cohort Studies; Dataset; Diagnosis; Epidemiology; Fasting; Glucose; Hemoglobin A, Glycosylated; Homeostasis; Humans; Insulin Resistance; Korea; Nutrition Surveys; Obesity; ROC Curve; Waist Circumference
- From:Journal of Korean Medical Science 2019;34(6):e48-
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Continuous metabolic syndrome (MS) severity scores that can track metabolic risk in individuals over time have been developed for Western populations. The present study aimed to develop gender- and age-specific equations for MS severity scores in Korean adults. METHODS: Using data from the Korea National Health and Nutrition Examination Surveys (KNHANES) IV (2010–2012) and VI (2013–2015), we performed a confirmatory factor analysis of single MS factor that allowed for differential loadings across groups to generate gender- and age-specific, continuous MS severity scores. Then, we validated this equation in a different dataset of Korean adults. RESULTS: In confirmatory analysis, waist circumference had the highest factor loading, indicating that waist circumference had the strongest correlation with MS among Korean adults. Lower factor loadings (< 0.4) among Korean adults aged 40–59 years were noted for systolic blood pressure and fasting glucose. MS severity score values were significantly correlated with metabolic parameters, including high-sensitivity C-reactive-protein, glycated hemoglobin, and homeostasis model assessment of insulin resistance. Furthermore, MS severity scores well predicted traditional MS according to receiver operating characteristic analysis in a validation dataset (KNHANES VII). In a longitudinal cohort dataset, participants diagnosed with Adult Treatment Program III (ATP-III) MS after an initial assessment had progressively higher baseline MS severity scores in relationship to their time until ATP-III MS diagnosis. CONCLUSION: The new MS severity score equations for Korean adults proposed in this study provide a clinically-accessible continuous measure of MS for potential use in identifying adults at higher risk for MS-related diseases and following changes within individuals over time.
