Cluster of Lymphadenitis due to Nontuberculous Mycobacterium in Children and Adolescents 8–15 Years of Age
10.3346/jkms.2019.34.e302
- Author:
Seul Gi PARK
1
;
Hyojin KIM
;
Jin Ho PAIK
;
Kyoung Un PARK
;
Jeong Su PARK
;
Woo Jin JEONG
;
Young Ho JUNG
;
Jung Im NA
;
Ki Hyuk SUNG
;
Ji Young KIM
;
Heeyoung LEE
;
Hyunju LEE
Author Information
1. Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. hyunjulee@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Nontuberculous Mycobacteria;
Mycobacterium haemophilum;
Mycobacterium;
Lymphadenitis;
Mycobacterial Cervical Lymphadenitis
- MeSH:
Adolescent;
Anti-Bacterial Agents;
Bacteria;
Biopsy;
Child;
Diagnosis;
Electronic Health Records;
Environmental Exposure;
Humans;
Inflammation;
Lymph Nodes;
Lymphadenitis;
Male;
Mycobacterium;
Mycobacterium haemophilum;
Nontuberculous Mycobacteria;
Polymerase Chain Reaction;
Tuberculosis, Lymph Node
- From:Journal of Korean Medical Science
2019;34(46):e302-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Nontuberculous mycobacteria (NTM) lymphadenitis is an under-recognized entity, and data of the true burden in children are limited. Without a high index of suspicion, diagnosis may be delayed and microbiological detection is challenging. Here, we report a cluster of NTM lymphadenitis experienced in Korean children. METHODS: Subjects under 19 years of age diagnosed with NTM lymphadenitis during November 2016–April 2017 and April 2018 were included. Electronic medical records were reviewed for clinical, laboratory and pathological findings. Information regarding underlying health conditions and environmental exposure factors was obtained through interview and questionnaires. RESULTS: A total of ten subjects were diagnosed during 18 months. All subjects were 8–15 years of age, previously healthy, male and had unilateral, nontender, cervicofacial lymphadenitis for more than 3 weeks with no significant systemic symptoms and no response to empirical antibiotics. Lymph nodes involved were submandibular (n = 8), preauricular (n = 6) and submental (n = 1). Five patients had two infected nodes and violaceous discoloration was seen in seven subjects. Biopsy specimens revealed chronic granulomatous inflammation and acid-fast bacteria culture identified Mycobacterium haemophilum in two cases and NTM polymerase chain reaction was positive in two cases. Survey revealed various common exposure sources. CONCLUSION: NTM lymphadenitis is rare but increasing in detection and it may occur in children and adolescents. Diagnosis requires high index of suspicion and communication between clinicians and the laboratory is essential for identification of NTM.
