Recent Trends in Demographics, Surgery, and Prognosis of Patients with Surgically Resected Lung Cancer in a Single Institution from Korea
10.3346/jkms.2019.34.e291
- Author:
Jae Kwang YUN
1
;
Han Pil LEE
;
Geun Dong LEE
;
Hyeong Ryul KIM
;
Yong Hee KIM
;
Dong Kwan KIM
;
Seung Il PARK
;
Sehoon CHOI
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. choishn@gmail.com
- Publication Type:Original Article
- Keywords:
Time Trend;
Demography;
Surgical Resection;
Surgical Outcome;
Non-Small Cell Lung Cancer;
Republic of Korea
- MeSH:
Adenocarcinoma;
Aged;
Carcinoma, Non-Small-Cell Lung;
Demography;
Female;
Humans;
Korea;
Lung Neoplasms;
Lung;
Prognosis;
Republic of Korea;
Retrospective Studies;
Survival Rate;
Thoracic Surgery, Video-Assisted
- From:Journal of Korean Medical Science
2019;34(45):e291-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Over the past few decades, demographics information has changed significantly in patients with surgically resected lung cancer. Herein, we evaluated the recent trends in demographics, surgery, and prognosis of lung cancer surgery in Korea. METHODS: Patients with surgically resected primary lung cancer from 2002 to 2016 were retrospectively analyzed. Multivariable Cox regression analysis was conducted to identify prognostic factors for overall survival. The annual percent change (APC) and statistical significance were calculated using the Joinpoint software. RESULTS: A total of 7,495 patients were enrolled. Over the study period, the number of lung cancer surgeries continued to increase (P < 0.05). The proportion of women to total subjects has also increased (P < 0.05). The proportion of elderly patients (≥ 70 years) as well as those with tumors measuring 1–2 cm and 2–3 cm significantly increased in both genders (all P < 0.05). The proportion of patients with adenocarcinoma, video-assisted thoracic surgery, sublobar resection, and pathological stage I significantly increased (P < 0.05). The 5-year overall survival rate of lung cancer surgery increased from 61.1% in 2002–2006 to 72.1% in 2012–2016 (P < 0.001). The operative period was a significant prognostic factor in multivariable Cox analysis (P < 0.001). CONCLUSION: The mean age of patients with lung cancer surgery increased gradually, whereas tumor size reduced. Prognosis of lung cancer surgery improved with recent increases in the frequency of adenocarcinoma, video-assisted thoracic surgery, sublobar resection, and pathological stage I. The operation period itself was also an independent prognostic factor for overall survival.
