The First Case of Para-Bombay Blood Type Encountered in a Korean Tertiary Hospital
10.3346/jkms.2019.34.e258
- Author:
Min Sun KIM
1
;
Jin Seok KIM
;
Hyewon PARK
;
Yousun CHUNG
;
Hyungsuk KIM
;
Dae Hyun KO
;
Sung Han KIM
;
Sang Hyun HWANG
;
Heung Bum OH
Author Information
1. Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. daehyuni1118@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Human FUT1 Protein;
Human FUT2 Protein;
H Blood Group System
- MeSH:
ABO Blood-Group System;
Agglutination;
Anemia;
Asian Continental Ancestry Group;
B-Lymphocytes;
Blood Group Antigens;
Blood Transfusion;
Erythrocytes;
Fever;
Humans;
Indicators and Reagents;
Korea;
Mycobacterium Infections, Nontuberculous;
Phenotype;
Tertiary Care Centers;
Young Adult
- From:Journal of Korean Medical Science
2019;34(39):e258-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Para-Bombay phenotypes are rare blood groups that have inherent defects in producing H antigens associated with FUT1 and/or FUT2. We report the first case of para-Bombay blood type in a Southeast Asian patient admitted at a tertiary hospital in Korea. A 23-year-old Indonesian man presented to the hospital with fever and was diagnosed with a disseminated nontuberculous mycobacterium infection and anemia. During blood group typing for blood transfusion, cell typing showed no agglutination with both anti-A and anti-B reagents. Serum typing showed strong reactivity against B cells and trace agglutination pattern with A1 cells. His red blood cells failed to react with anti-H reagents. Direct sequencing of FUT1 and FUT2 revealed a missense variation, c.328G>A (p.Ala110Thr, rs56342683, FUT1*01W.02), and a synonymous variant, c.390C>T (p.Asn130=, rs281377, Se³⁵⁷), respectively. This highlights the need for both forward and reverse grouping.
