Bidirectional Association between First-Episode Panic Disorder and Major Depressive Disorder in a Nationwide General Population Survey in Korea
10.3346/jkms.2019.34.e181
- Author:
Jungmin WOO
1
;
Jin Pyo HONG
;
Seong Jin CHO
;
Jun Young LEE
;
Hong Jin JOEN
;
Byung Soo KIM
;
Sung Man CHANG
Author Information
1. Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea. psyjang@hanmail.net
- Publication Type:Original Article
- Keywords:
Lifetime Prevalence;
Hazard Ratios;
Composite International Diagnostic Interview;
Age of Onset;
Panic Disorder;
Major Depressive Disorder
- MeSH:
Age of Onset;
Comorbidity;
Depressive Disorder, Major;
Humans;
Kaplan-Meier Estimate;
Korea;
Panic Disorder;
Panic;
Proportional Hazards Models
- From:Journal of Korean Medical Science
2019;34(26):e181-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Panic disorder (PD) and major depressive disorder (MDD) can occur concurrently, despite different clinical manifestations. Because MDD and PD patients tend to have more complicated conditions, understanding the co-occurrence and pattern of these conditions is important. Here, we investigated the influence of PD and MDD on each other, with respect to time interval. METHODS: Data from three national representative surveys were pooled (total 18,807 respondents), and the age of onset (AOO) of PD and MDD was analyzed. We performed Kaplan-Meier analysis to estimate separate survival functions, using the AOO of MDD and PD as the outcome. To understand the temporal effect of other disorders, we used a Cox proportional hazard model to estimate the hazard ratios for the onset of MDD/PD with other comorbidities as time-dependent covariates. RESULTS: PD elevated the risk of subsequent MDD by 1.5-fold, whereas MDD elevated the risk of subsequent PD by 3.8-fold. The effect of such an elevation risk was significant for up to 2 years. CONCLUSION: The results revealed a bidirectional relationship between MDD and PD. Each disease represents a risk of a subsequent occurrence of the other, which lasts for a considerable duration.
