Associations between the HaeIII Single Nucleotide Polymorphism in the SLC2A1 Gene and Diabetic Nephropathy in Korean Patients with Type 2 Diabetes Mellitus
10.3346/jkms.2019.34.e171
- Author:
Dong Hwa LEE
1
;
Gun Woo WON
;
Yong Hee LEE
;
Eu Jeong KU
;
Tae Keun OH
;
Hyun Jeong JEON
Author Information
1. Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea. endoann@daum.net
- Publication Type:Original Article
- Keywords:
Polymorphism;
SLC2A1;
HaeIII;
Diabetic Nephropathies;
Diabetes Mellitus, Type 2
- MeSH:
Cardiovascular Diseases;
Cerebrovascular Disorders;
Chungcheongbuk-do;
Diabetes Complications;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Diabetic Nephropathies;
Genetic Predisposition to Disease;
Genotype;
Glucose Transport Proteins, Facilitative;
Humans;
Methods;
Peripheral Arterial Disease;
Peripheral Nervous System Diseases;
Polymorphism, Single Nucleotide;
Real-Time Polymerase Chain Reaction;
Renal Insufficiency
- From:Journal of Korean Medical Science
2019;34(24):e171-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Diabetic nephropathy (DN) is the most serious microvascular complication of diabetes mellitus and is one of the leading causes of end stage renal failure. In previous studies, the contribution of genetic susceptibility to DN showed inconsistent results. In this study, we investigated the association between the solute carrier family 2 facilitated glucose transporter member 1 (SLC2A1) HaeIII polymorphism and DN in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration. METHODS: A total of 846 patients with T2DM (mean age, 61.3 ± 12.3 years; mean duration of T2DM, 10.3 ± 7.9 years; 55.3% men) who visited the Chungbuk National University Hospital were investigated. The HaeIII polymorphism of the SLC2A1 gene was determined by the real time polymerase chain reaction method. Genotyping results were presented as GG, AG, or AA. A subgroup analysis was performed according to duration of T2DM (≤ 10 years, < 10 years). RESULTS: The AG + AA genotype showed a significantly higher risk of DN compared with the GG genotype in patients with a type 2 DM duration less than 10 years (12.4% vs. 4.2%; P < 0.001). No significant differences were observed in terms of other diabetic complications, including retinopathy, peripheral neuropathy, cardiovascular disease, cerebrovascular disease or peripheral artery disease, according to the genotypes of the SLC2A1 HaeIII polymorphism. CONCLUSION: The SLC2A1 HaeIII polymorphism was associated with DN in Korean patients with T2DM, particularly in the group with a relatively short disease duration.
