Correlation of Contrast-Enhanced MR Findings and Tumor Microvessel Density of Breast Masses.
10.3348/jkrs.2004.50.5.379
- Author:
Hae Won PARK
1
;
Shin Ho KOOK
;
Hyon Joo KWAG
Author Information
1. Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Korea. kook3@samsung.co.kr
- Publication Type:Original Article
- Keywords:
Breast neoplasms;
Breast, MR
- MeSH:
Breast Neoplasms;
Breast*;
Hand;
Magnetic Resonance Imaging;
Microvessels*;
Retrospective Studies
- From:Journal of the Korean Radiological Society
2004;50(5):379-384
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To compare the contrast-enhanced dynamic MR findings of solid breast masses with their histopathologic tumor angiogenesis. MATERIALS AND METHODS: Thirty-two cases of pathologically proved breast lesions (8 benign and 24 malignant lesions) examined with contrast-enhanced MRI were retrospectively reviewed, focusing on the tumor size, the maximum amount of contrast enhancement (% Signal Intensity Change, SIC), the time to peak (early or late peak) and the type of time-signal intensity curve (TSC). We compared the characteristic MR findings of breast cancer with the microscopic maximum microvessel density (MVD). RESULTS: Among the total of 11 small lesions (< or = 2 cm, 9 malignant and 2 benign), 8 cases of malignant lesions showed high MVD (> or = 20). On the other hand, among the 21 large lesions (> 2 cm, 15 malignant and 6 benign), only two cases of malignant and five cases of benign lesions showed high MVD. More than 100% SIC was observed in a total of 11 malignant and two benign lesions, but 8 of these 11 malignant lesions showed low MVD (< 20), whereas the two benign lesions showed high MVD. Early time to peak (< or = 3 min) was observed in 18 (17 malignant and 1 benign) lesions, and 11 of these 17 malignant lesions showed low MVD. An early high peak and early or slow wash-out pattern, which is typical of the malignant type, was seen in 18 (17 malignant and 1 benign) lesions, but 12 of these 17 malignant lesions showed low MVD. There is no statistically significant correlation between the characteristic MR findings of breast cancer and the MVD. CONCLUSION: Although high MVD indicated malignancy in the case of the small lesions, the histopathologic MVD was not significantly correlated with either the increased amount of enhancement, early time-to peak or the malignant pattern of the TSC.
