Influence of Short- and Long-term High-dose Caffeine Administration on Behavior in an Animal Model of Adolescence
10.7586/jkbns.2019.21.3.217
- Author:
Jong Min PARK
1
;
Yoonju KIM
;
Haeun KIM
;
Youn Jung KIM
Author Information
1. College of Nursing Science, Kyung Hee University, Seoul, Korea. yj129@khu.ac.kr
- Publication Type:Original Article
- Keywords:
Caffeine;
Adolescent;
Locomotion;
Anxiety;
Memory
- MeSH:
Adolescent;
Animals;
Anxiety;
Behavior Rating Scale;
Caffeine;
Cognition;
Education;
Energy Drinks;
Grooming;
Humans;
Incidence;
Learning;
Locomotion;
Memory;
Models, Animal;
Motor Activity;
United Nations
- From:Journal of Korean Biological Nursing Science
2019;21(3):217-223
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction of energy drinks. However, little is known about the time-dependent effect of high doses of caffeine consumption in adolescents. The present study aims to examine the short- and long-term influence of high-dose caffeine on behavior of adolescence. METHODS: The animals were divided into three groups: a “vehicle” group, which was injected with 1 ml of phosphate-buffered saline for 14 days; a “Day 1” group, which was injected with caffeine (30 mg/kg), 2 h before the behavioral tests; and a “Day 14” group, which was infused with caffeine for 14 days. An open-field test, a Y-maze test, and a passive avoidance test were conducted to assess the rats'activity levels, anxiety, and cognitive function. RESULTS: High-dose caffeine had similar effects in short-and long-term treatment groups. It increased the level of locomotor activity and anxiety-like behavior, as evidenced by the increase in the number of movements and incidences of rearing and grooming in the caffeine-treated groups. No significant differences were observed between the groups in the Y-maze test. However, in the passive avoidance test, the escape latency in the caffeine-treated group was decreased significantly, indicating impaired memory acquisition. CONCLUSION: These results indicate that high-dose caffeine in adolescents may increase locomotor activity and anxiety-like behavior and impair learning and memory, irrespective of the duration of administration. The findings will be valuable for both evidence-based education and clinical practice.
