Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System).
- Author:
Yasunari SAKAMOTO
1
;
Yusuke SEKINO
;
Eiji YAMADA
;
Hidenori OHKUBO
;
Takuma HIGURASHI
;
Eiji SAKAI
;
Hiroshi IIDA
;
Kunihiro HOSONO
;
Hiroki ENDO
;
Takashi NONAKA
;
Tamon IKEDA
;
Koji FUJITA
;
Masato YONEDA
;
Tomoko KOIDE
;
Hirokazu TAKAHASHI
;
Ayumu GOTO
;
Yasunobu ABE
;
Eiji GOTOH
;
Shin MAEDA
;
Atsushi NAKAJIMA
;
Masahiko INAMORI
Author Information
1. Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan. inamorim@med.yokohama-cu.ac.jp
- Publication Type:Original Article
- Keywords:
Breath test;
Gastric emptying;
Mosapride;
Pectin
- MeSH:
Benzamides;
Breath Tests;
Cross-Over Studies;
Fasting;
Gastric Emptying;
Gastroesophageal Reflux;
Humans;
Male;
Meals;
Morpholines;
Pectins
- From:Journal of Neurogastroenterology and Motility
2011;17(4):395-401
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals. METHODS: Six healthy male volunteers underwent 3 tests at intervals of > 1 week. After fasting for > 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A 13C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (beta version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test. RESULTS: Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone. CONCLUSIONS: This study showed that high-viscosity liquid meals delayed gastric emptying: however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals.
