Conservative hysteroscopic treatment of stage I well differentiated endometrial cancer in patients with high surgical risk: a pilot study
- Author:
Paolo CASADIO
1
;
Francesca GUASINA
;
Maria Rita TALAMO
;
Roberto PARADISI
;
Ciro MORRA
;
Giulia MAGNARELLI
;
Renato SERACCHIOLI
Author Information
- Publication Type:Original Article
- Keywords: Endometrial Cancer; Hysteroscopic Surgery; Obesity; High Surgical Risk
- MeSH: Brachytherapy; Endometrial Neoplasms; Female; Follow-Up Studies; Hospitalization; Humans; Hysteroscopy; Intrauterine Devices; Obesity; Pilot Projects; Prospective Studies; Recurrence
- From:Journal of Gynecologic Oncology 2019;30(4):e62-
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To report hysteroscopic treatment combined with levonorgestrel-releasing intrauterine device (LNG-IUD) to treat women with early well differentiated endometrial cancer (EC) at high surgical risk. METHODS: Nine women diagnosed with stage IA, grade 1 endometrioid EC which was contraindicated or refused standard treatment with external beam radiation therapy with or without brachytherapy were enrolled in our prospective study. Endo-myometrial hysteroscopic resection of the whole uterine cavity and the placement of LNG-IUD for 5 years was performed. Response rate, perioperative complications, and recurrence of disease were evaluated. RESULTS: None had intra or post-operative complications and all were discharged no later than the third day of hospitalization. After 6 months from surgery, all the women showed a complete regression of the lesion. All the women completed the 5 years follow-up and in no case was detected sign of recurrence. Two women died for causes unrelated to the tumor or the ongoing therapy. CONCLUSION: The alternative treatment with endo-myometrial hysteroscopic resection and LNG-IUD in women with stage IA, grade 1 endometrioid EC showed initial encouraging outcomes in terms of effectiveness and safety.
