Chromophobe Cell Renal Carcinoma: A Report of Four Cases with DNA Ploidy and Ultrastructural Study.
- Author:
Chang Hee HAN
1
;
Yeong Jin CHOI
;
Sue Yong SUNG
;
Sung Hak KANG
;
Jai Young YOON
;
Tae Kon HWANG
;
Eun Jung LEE
Author Information
1. Department of Urology, College of Medicine, Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Chromophobe cell renal carcinoma;
Electron microscopy;
Flow cytometry
- MeSH:
Aneuploidy;
Colloids;
Cytoplasm;
DNA*;
Eosinophils;
Flank Pain;
Flow Cytometry;
Follow-Up Studies;
Hematuria;
Humans;
Iron;
Keratins;
Microscopy, Electron;
Mucin-1;
Ploidies*;
Vimentin
- From:Korean Journal of Urology
1998;39(1):91-96
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We present four cases of the recently characterized chromophobe cell renal carcinoma. Gross hematuria, palpable flank mass and flank pain were the main symptoms of patients. With chromophobe cell renal carcinoma all tumors were solitary pale brown or beige colored mass, ranging from 6.0 to 10.5cm in diameter. Microscopically two cases were typical type and the other two cases were eosiophilic type. All of them showed strong reactivity for Hale's colloidal iron stain, cytokeratin and epithelial membrane antigen, but negative for vimentin. Ultrastructually characteristic invaginated microvesicles, 180-440nm in diameter, were identified in the cytoplasm. DNA ploidy studies revealed an aneuploid cell population in two cases of eosinophilic type. No patients showed recurrent tumor during the follow up periods, ranging from 5 to 92months.
