Evaluation of the Clinical Effect of Intravenous Glutamine on Intensive Care Unit Patients
10.15747/jcn.2019.11.1.23
- Author:
Kwang Joon KIM
1
;
Hey Young JANG
;
Min Ku KANG
Author Information
1. Department of Pharmacy, Chosun University Hospital, Gwangju, Korea. nocky@hanmail.net
- Publication Type:Multicenter Study
- Keywords:
Glutamine;
Intensive care units;
Clinical effect
- MeSH:
Critical Care;
Glutamine;
Hospital Mortality;
Hospitals, General;
Humans;
Intensive Care Units;
Length of Stay;
Mortality
- From:Journal of Clinical Nutrition
2019;11(1):23-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the clinical effect of intravenous glutamine administration on patients admitted to the intensive care unit in general hospitals. METHODS: Patients with more than 7 days in an intensive care unit were evaluated. The experimental group was the patients who received intravenous glutamine administration for more than 3 days. The laboratory results, intensive care unit length of stay, hospital length of stay, 30 days mortality, and hospital mortality were evaluated with a comparative group. RESULTS: The mean number of administration days of intravenous glutamine was 10.12±8.93 days, and the average daily dose was 0.33±0.10 g/kg/day. No adequate improvement in the laboratory results of glutamine-treated group was observed. The intensive care unit length of stay (21.16±15.83 vs. 16.48±11.06, P=0.007), hospital length of stay (35.94±30.75 vs. 27.34±19.09, P=0.010), 30 days mortality (20.0% vs. 10.0%, P=0.034), and hospital mortality (26.3% vs. 13.0%, P=0.001) were higher in the glutamine-treated group. CONCLUSION: The use of intravenous glutamine on intensive care unit patients did not improve the clinical effect. Further large-scale multi-center studies will be needed to assess the proper administration of intravenous glutamine on intensive care unit patients.
