Effect of Modified Ultrafiltration on Pediatric Open Heart Surgery.
- Author:
Kwang Sook LEE
1
;
Young Sun YOO
;
Sae Young CHOI
;
Chang Kwon PARK
;
Dae Yung CHOI
;
Gyung Chan YOON
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Keimyung University, School of Medicine, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Ultrafiltration;
Cardiopulmonary bypass
- MeSH:
Arterial Pressure;
Blood Pressure;
Body Water;
Cardiopulmonary Bypass;
Child;
Edema;
Fibrinogen;
Heart*;
Hematocrit;
Hemodynamics;
Humans;
Platelet Count;
Prospective Studies;
Thoracic Surgery*;
Ultrafiltration*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
1998;31(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Total body water is increased after cardiopulmonary bypass resulting in tissue edema and organ dysfunction. Ultrafiltration has been used to reduce this accumulation of water. We have carried out a prospective randomized study in 17 children undergoing open heart surgery, comparing modified ultrafiltration (MUF) with nonfiltered controls. MUF was carried out for about 10 minutes after completion of cardiopulmonary bypass to a hematocrit 36~42%. Blood loss, blood transfused, hemodynamics, and laboratory data were recorded for 24 hours postoperatively. The results were analyzed using Mann-Whitney U test, comparing controls (n=7) to ultrafiltered (n=10). There was no death in each group. The mean filtrate volume (ml/kg) was 42 (30~68). Blood loss (ml/kg/24hr) was 14.5 mean (4.0~26.6) in controls versus 12.1 mean (6.0~21.5) in MUF (p>0.05) ; blood transfused (ml/kg/24hr) was 9.4 mean (6.0~36.3) in controls versus 3.4 mean (0~11.4) in MUF (p<0.05). There was rise in arterial blood pressure during MUF. Percent rise of systolic blood pressure was 4.2 (0~11.7) in controls versus 19.8 (7.0~36.9) in MUF (P=0.001). Percent rise of diastolic blood pressure was 10.0 (1.6~20.8) in controls versus 30.6 (5.8~73.3) in MUF (p<0.05). Platelet count, fibrinogen, and oncotic pressure rose after MUF. No complications directly attributable to the ultrafiltration were observed. Conclusively, MUF is safe, effective means of removing body water and beneficial to hemodynamics.
