Elevated Serum Uric Acid in Benign Convulsions with Mild Gastroenteritis in Children
10.3988/jcn.2019.15.4.496
- Author:
Il Han YOO
1
;
Woojoong KIM
;
Jaeso CHO
;
Hunmin KIM
;
Byung Chan LIM
;
Hee HWANG
;
Jong Hee CHAE
;
Jieun CHOI
;
Ki Joong KIM
Author Information
1. Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea. 5714@snubh.org
- Publication Type:Original Article
- Keywords:
gastroenteritis;
seizure;
uric acid
- MeSH:
Child;
Dehydration;
Gastroenteritis;
Humans;
Retrospective Studies;
Seizures;
Seizures, Febrile;
Uric Acid
- From:Journal of Clinical Neurology
2019;15(4):496-501
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: To identify whether serum uric acid levels are significantly higher in patients with benign convulsion associated with mild gastroenteritis (CwG) than in patients with acute gastroenteritis. METHODS: This retrospective study compared the serum levels of uric acid between CwG, acute gastroenteritis, and febrile seizure after correcting for the varying degree of mild dehydration using serum HCO3⁻ levels. We also compared the serum uric acid levels between patients with CwG and febrile seizures in order to exclude the effect of seizures on uric acid. RESULTS: This study included 154 CwG patients (age range 0.73–3.19 years), 2,938 patients with acute gastroenteritis, and 154 patients with febrile seizure. The serum uric acid level was significantly higher in CwG patients than in patients with acute gastroenteritis [9.79±2.16 mg/dL vs. 6.04±2.3 mg/dL (mean±SD), p<0.001]. This difference was also significant after correcting for dehydration. The serum uric acid level was significantly higher in CwG patients than in dehydration-corrected acute gastroenteritis patients (9.79±2.16 mg/dL vs. 6.67±2.48 mg/dL, p<0.001). The serum uric acid level was not elevated in patients with febrile seizure. CONCLUSIONS: We have confirmed that serum uric acid is elevated in CwG patients even after correcting for their dehydration status, and that this was not a postictal phenomenon. Highly elevated serum uric acid in CwG could be a useful clinical indicator of CwG in patients with acute gastroenteritis.
