Relationships between ¹⁸F-THK5351 Retention and Language Functions in Primary Progressive Aphasia
10.3988/jcn.2019.15.4.527
- Author:
Hye Jin JEONG
1
;
Cindy W YOON
;
Seongho SEO
;
Sang Yoon LEE
;
Mee Kyung SUH
;
Ha Eun SEO
;
Woo Ram KIM
;
Hyon LEE
;
Jae Hyeok HEO
;
Yeong Bae LEE
;
Kee Hyung PARK
;
Seong Hye CHOI
;
Tatsuo IDO
;
Kyoung Min LEE
;
Young NOH
Author Information
1. Neuroscience Research Institute, Gachon University, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
primary progressive aphasia;
neurofibrillary tangles;
positron-emission tomography;
language
- MeSH:
Aphasia, Primary Progressive;
Cognition;
Comprehension;
Humans;
Magnetic Resonance Imaging;
Neurofibrillary Tangles;
Neuropsychological Tests;
Parietal Lobe;
Positron-Emission Tomography;
Prefrontal Cortex;
Rabeprazole;
Semantics;
Temporal Lobe
- From:Journal of Clinical Neurology
2019;15(4):527-536
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: There are three distinct subtypes of primary progressive aphasia (PPA): the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [¹⁸F]-THK5351 retention across all three subtypes and determine the topography of [¹⁸F]-THK5351 retention correlated with each neurolinguistic score. METHODS: We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 lvPPA) and 37 subjects with normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging, [¹⁸F]-THK5351 positron-emission tomography scans, and detailed neuropsychological tests. The PPA patients additionally participated in extensive neurolinguistic tests. Voxel-wise and region-of-interest-based analyses were performed to analyze [¹⁸F]-THK5351 retention. RESULTS: The nfvPPA patients exhibited higher [¹⁸F]-THK5351 retention in the the left inferior frontal and precentral gyri. In svPPA patients, [¹⁸F]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared to the NC group (left>right). The lvPPA patients exhibited predominant [¹⁸F]-THK5351 retention in the inferior parietal, lateral temporal, and dorsolateral prefrontal cortices, and the precuneus (left>right). [¹⁸F]-THK5351 retention in the left inferior frontal area was associated with lower fluency scores. Comprehension was correlated with [¹⁸F]-THK5351 retention in the left temporal cortices. Repetition was associated with [¹⁸F]-THK5351 retention in the left inferior parietal and posterior temporal areas, while naming difficulty was correlated with retention in the left fusiform and temporal cortices. CONCLUSIONS: The pattern of [¹⁸F]-THK5351 retention was well matched with clinical and radiological findings for each PPA subtype, in agreement with the anatomical and functional location of each language domain.
