The Role of Peroxiredoxin Family in Cancer Signaling
10.15430/JCP.2019.24.2.65
- Author:
Yosup KIM
1
;
Ho Hee JANG
Author Information
1. Department of Health Sciences and Technology, Graduate School of Medicine, Gachon University, Incheon, Korea. hhjang@gachon.ac.kr
- Publication Type:Review
- Keywords:
Peroxiredoxins;
Oxidative stress;
Cancer;
Peroxidase activity;
Tumorigenesis
- MeSH:
Apoptosis;
Carcinogenesis;
Homeostasis;
Humans;
Metabolism;
Oxidative Stress;
Peroxiredoxins;
Physiological Processes;
Prognosis;
Protein Isoforms;
Reactive Oxygen Species
- From:Journal of Cancer Prevention
2019;24(2):65-71
- CountryRepublic of Korea
- Language:English
-
Abstract:
Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells, the six Prx isoforms are ubiquitously expressed in diverse intracellular locations. They are involved in the regulation of various physiological processes including cell growth, differentiation, apoptosis, immune response and metabolism as well as intracellular ROS homeostasis. Although there are increasing evidences that Prxs are involved in carcinogenesis of many cancers, their role in cancer is controversial. The ROS levels in cancer cells are increased compared to normal cells, thus promoting cancer development. Nevertheless, for various cancer types, an overexpression of Prxs has been found to be associated with poor patient prognosis, and an increasing number of studies have reported that tumorigenesis is either facilitated or inhibited by regulation of cancer-associated signaling pathways. This review summarizes Prx isoforms and their basic functions, the relationship between the expression level and the physiological role of Prxs in cancer cells, and their roles in regulating cancer-associated signaling pathways.
