Primary Histiocytic Sarcoma Presenting as a Breast Mass: A Case Report
- Author:
Seongsik BANG
1
;
Yeseul KIM
;
Min Sung CHUNG
;
Jeong Seon PARK
;
Yun Young CHOI
;
Su Jin SHIN
Author Information
- Publication Type:Case Report
- Keywords: Breast; Histiocytes; Histiocytic sarcoma; True histiocytic lymphoma
- MeSH: Aged; Breast; Cytoplasm; Eosinophils; Female; Giant Cells; Hematologic Neoplasms; Histiocytes; Histiocytic Sarcoma; Humans; Neoplasm Metastasis; Recurrence
- From:Journal of Breast Cancer 2019;22(3):491-496
- CountryRepublic of Korea
- Language:English
- Abstract: Histiocytic sarcoma is a rare hematologic malignancy, with very few cases of primary histiocytic sarcoma of the breast described in English scientific literature. Herein, we describe a case of primary histiocytic sarcoma of the breast in a 75-year-old woman, with no clinical history of malignant tumors, who presented with a palpable solitary breast mass. Microscopically, the resected breast mass showed large pleomorphic cells, some multinucleated giant cells, and admixed inflammatory components. The pleomorphic tumor cells further showed a diffuse, noncohesive growth pattern, an abundant eosinophilic cytoplasm, and strong and diffuse immunoreactivity for cluster of differentiation (CD) 68 and CD163. Furthermore, a whole-body positron-emission tomography/computed tomography using deoxy-2-[¹⁸F]fluoro-D-glucose performed after surgery showed no other masses or lesions. After surgical excision, the patient was followed up, and no evidence of tumor recurrence or metastasis was noted.
