Association Between Toxin-antitoxin Systems on Plasmids and Persister Formation in CTX-15-producing Klebsiella pneumoniae ST11 Isolates
- Author:
Eun Seon CHUNG
1
;
So Yeon KIM
;
Kwan Soo KO
Author Information
- Publication Type:Original Article
- Keywords: persister; toxin-antitoxin (TA) system; CTX-M-15, ppGpp
- MeSH: Klebsiella pneumoniae; Klebsiella; Plasmids
- From:Journal of Bacteriology and Virology 2019;49(2):53-58
- CountryRepublic of Korea
- Language:English
- Abstract: We investigated the effect of toxin-antitoxin (TA) systems in bla(CTX-M-15)-bearing plasmids of Klebsiella pneumoniae on persister formation. The persister formation rate was notably high in transconjugants in plasmids bearing TA system than the transconjugants in plasmids bearing no TA systems. Activation of relA and spoT expression was higher in transconjugants with plasmids bearing TA systems. Thus, TA systems in plasmids may contribute to the maintenance of bla(CTX-M-15)-bearing plasmids and host survival via persister formation.
