Risk of surgery in patients with stricturing type of Crohn's disease at the initial diagnosis: a single center experience
- Author:
Yuji MAEHATA
1
;
Yutaka NAGATA
;
Tomohiko MORIYAMA
;
Yuichi MATSUNO
;
Atsushi HIRANO
;
Junji UMENO
;
Takehiro TORISU
;
Tatsuya MANABE
;
Takanari KITAZONO
;
Motohiro ESAKI
Author Information
- Publication Type:Original Article
- Keywords: Crohn disease; Stricturing type; Intestine, small; Surgery; Biological therapy
- MeSH: Biological Therapy; Constriction, Pathologic; Crohn Disease; Diagnosis; Follow-Up Studies; Humans; Incidence; Intestine, Small; Multivariate Analysis; Radiography; Retrospective Studies
- From:Intestinal Research 2019;17(3):357-364
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: It remains uncertain which patients with stricturing-type Crohn's disease (CD) require early small bowel surgery after the initial diagnosis. We aimed to clarify clinical characteristics associated with the intervention in such condition of CD. METHODS: We retrospectively evaluated the clinical course of 53 patients with CD and small bowel strictures who were initially treated with medications after the initial diagnosis. We investigated possible associations between small bowel surgery and the following: clinical factors and radiologic findings at initial diagnosis and the types of medications administered during follow-up. RESULTS: Twenty-eight patients (53%) required small bowel resection during a median follow-up period of 5.0 years (range, 0.5–14.3 years). The cumulative incidence rates of small bowel surgery at 2, 5, and 10 years were 26.4%, 41.0%, and 63.2%, respectively. Univariate analysis indicated that obstructive symptoms (P=0.036), long-segment stricture (P<0.0001), and prestenotic dilation (P<0.0001) on radiography were associated with small bowel surgery, and immunomodulatory (P=0.037) and biological therapy (P=0.008) were significant factors during follow-up. Multivariate analysis revealed that long-segment stricture (hazard ratio [HR], 4.25; 95% confidence interval [CI], 1.78–10.53; P=0.001) and prestenotic dilation (HR, 3.41; 95% CI, 1.24–9.62; P=0.018) on radiography showed a positive correlation with small bowel surgery, and biological therapy (HR, 0.40; 95% CI, 0.15–0.99; P=0.048) showed a negative correlation. CONCLUSIONS: CD patients with long-segment stricture and prestenotic dilation on radiography seem to be at a higher risk of needing small bowel surgery. For such patients, early surgical intervention might be appropriate, even at initial diagnosis.
