Alpha-1 Adrenergic Receptor Blockers for the Treatment of Lower Urinary Tract Symptoms in Women: A Systematic Review and Meta-Analysis
- Author:
Do Kyung KIM
1
;
Joo Yong LEE
;
Jae Hung JUNG
;
Jae Heon KIM
;
Yoon Soo HAH
;
Chang Hee HONG
;
Kang Su CHO
Author Information
- Publication Type:Meta-Analysis
- Keywords: Alpha-adrenergic antagonists; Lower urinary tract symptoms; Voiding dysfunction; Women; Meta-analysis
- MeSH: Female; Humans; Lower Urinary Tract Symptoms; Prospective Studies; Receptors, Adrenergic, alpha-1
- From:International Neurourology Journal 2019;23(1):56-68
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To assess the effectiveness of alpha-1 adrenergic receptor blockers (α1-blockers) in the treatment of female lower urinary tract symptoms (LUTS). METHODS: A literature search was conducted using the PubMed/MEDLINE, Embase, and Cochrane Library databases. Fourteen studies with 1,319 patients were ultimately included. The study comprised 2 analyses: a comparison of urinary symptom scores, maximal flow rate (Qmax), and postvoid residual (PVR) urine volume before and after α1-blocker administration in 8 prospective, open-label studies and 5 randomized clinical trials (RCTs); and an evaluation of the same variables in α1-blocker and placebo groups in 4 RCTs.
