Trifolium pratense induces apoptosis through caspase pathway in FaDu human hypopharynx squamous carcinoma cells
10.11620/IJOB.2019.44.3.81
- Author:
Seul Ah LEE
1
;
Bo Ram PARK
;
Chun Sung KIM
Author Information
1. Department of Oral Biochemistry, College of Dentistry, Chosun University, Gwangju 61452, Republic of Korea. cskim2@chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Oral cancer;
Trifolium pratense;
Apoptosis
- MeSH:
Apoptosis;
Asthma;
Blotting, Western;
Carcinoma, Squamous Cell;
Caspase 3;
Down-Regulation;
Eczema;
Female;
Flow Cytometry;
Humans;
Hypopharynx;
Medicine, Traditional;
Methanol;
Mouth Neoplasms;
Plants;
Trifolium;
Up-Regulation;
Whooping Cough
- From:International Journal of Oral Biology
2019;44(3):81-88
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Trifolium pratense leaves (red clover) has been used in Oriental and European folk medicine for the treatment of whooping cough, asthma, and eczema, and is now being used to treat and alleviate the symptoms, such as hot flushes, cardiovascular health effects that occur in postmenopausal women. However, relatively little scientific data is available on the physiological activity of this plant. Therefore, in this study, we investigated the anti-cancer activity of T. pratense leaves using methanol extract of T. pratense leaves (MeTP) on human FaDu hypopharyngeal squamous carcinoma cells. MeTP inhibited the viability of FaDu cells by inducing apoptosis through the cleavage of procaspase-3,
