Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
10.11620/IJOB.2019.44.1.20
- Author:
Yeon KIM
1
;
Joo Yeon PARK
;
Hyun Joo PARK
;
Mi Kyoung KIM
;
Yong Il KIM
;
Soo Kyung BAE
;
Hyung Joon KIM
;
Moon Kyoung BAE
Author Information
1. Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea. mkbae@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Porphyromonas gingivalis;
Vascular smooth muscle cells;
Matrix metalloproteinase 9;
STAT3 transcription factor
- MeSH:
Animals;
Atherosclerosis;
Cardiovascular Diseases;
Cell Movement;
Matrix Metalloproteinase 9;
Muscle, Smooth, Vascular;
Periodontal Diseases;
Porphyromonas gingivalis;
Porphyromonas;
Rats;
RNA, Messenger;
STAT3 Transcription Factor;
Transducers
- From:International Journal of Oral Biology
2019;44(1):20-26
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of atherosclerosis. In the present study, we demonstrated that P. gingivalis lipopolysaccharide (LPS) increases the mRNA and protein expression of matrix metalloproteinase-9 (MMP-9) in rat vascular smooth muscle cells. We showed that the MMP-9 expression induced by P. gingivalis LPS is mediated by the activation of signal transducer and activator of transcription 3 (STAT3) in vascular smooth muscle cells. Furthermore, the inhibition of STAT3 activity reduced P. gingivalis LPS-induced migration of vascular smooth muscle cells. Overall, our findings indicate that P. gingivalis LPS stimulates the migration of vascular smooth muscle cells via STAT3-mediated MMP-9 expression.
