Clinical Features and Treatment Outcome of Chordoid Meningiomas in a Single Institute.
10.3340/jkns.2014.56.3.194
- Author:
Tae Keun JEE
1
;
Kyung Il JO
;
Ho Jun SEOL
;
Doo Sik KONG
;
Jung Il LEE
;
Hyung Jin SHIN
Author Information
1. Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. shinhj@skku.edu
- Publication Type:Original Article
- Keywords:
Chordoid meningioma;
MIB-1 labeling index;
Adjuvant radiation therapy
- MeSH:
Central Nervous System;
Disease-Free Survival;
Follow-Up Studies;
Humans;
Medical Records;
Meningioma*;
Recurrence;
Retrospective Studies;
Treatment Outcome*
- From:Journal of Korean Neurosurgical Society
2014;56(3):194-199
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Meningioma is the second most common primary central nervous system neoplasm. In contrast, chordoid meningioma is rare; due to the paucity of cases, little is known about its clinical features or treatment outcomes. The objectives of this study were to describe the clinical characteristics and outcomes for patients with chordoid meningioma. METHODS: In total, 16 patients, with newly diagnosed chordoid meningioma who underwent surgical excision between 1999 and 2012 were included. We retrospectively evaluated the medical records, radiological findings, and pathological findings. The median follow-up period was 56.5 (range, 3-170) months. The MIB-1 labeling index ranged from 1 to 26.60% (median, 5.04). RESULTS: Simpson grade I, II, and III resections were performed in four, nine, and three patients, respectively. The overall recurrence rate was 37.5%. Overall progression-free survival (PFS) after resection was 94.7 months (95% CI=62.9-126.6). Of the 4 patients with Simpson grade I resection, recurrence occurred in one patient. Among the Simpson grade II and III resection groups, eight patients underwent adjuvant radiation therapy and they showed significantly longer PFS (121 months, 95% CI=82.1-159.9) than the patients who underwent surgery alone (40.5 months, 95% CI=9.6-71.3) by the log-rank test (p<0.05). CONCLUSION: Chordoid meningiomas are difficult to manage and have a high rate of recurrence. Complete resection of the tumor is a key determinant of better outcomes. Adjuvant radiation therapy is recommended, eparticulary when Simpson grade I resection was not achieved.
