A case of bronchial asthma due to cefadroxil in a housewife.
- Author:
Jeong Hee CHOI
1
;
Yu Jin SUH
;
Jae Wook JUNG
;
Hyun Joo SONG
;
Chang Hee SUH
;
Dong Ho NAHM
;
Hae Sim PARK
Author Information
1. Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@madang.ajou.ac.kr
- Publication Type:Case Report
- Keywords:
asthma;
skin prick test;
cefadroxil;
cefaclor
- MeSH:
Adult;
Angioedema;
Asthma*;
Asthma, Occupational;
Bronchial Provocation Tests;
Cefaclor;
Cefadroxil*;
Cephalosporins;
Cough;
Dyspnea;
Female;
Humans;
Inhalation;
Occupational Exposure;
Pruritus;
Respiratory Tract Infections;
Sensation;
Skin;
Urticaria
- From:Journal of Asthma, Allergy and Clinical Immunology
2002;22(4):736-741
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cephalosporins are the most important -lactams that induce IgE-mediated reactions. Also, cephalosporins have been known as a causative agent for occupational asthma in pharmaceutical workers. To our knowledge, this is the first report of cephalosporin-induced bronchial asthma in a housewife with no history of occupational exposure. We experienced a 30-year old female who had developed shortness of breath, coughing and itching sensation of the skin since 3 years ago whenever she handled drug powder for upper respiratory infections (URI) prescribed for her two sons with bronchial asthma. She had handled drug powder for 7 years because her sons had experienced frequent URI. Skin prick test with cefadroxil (10mg/ml) and cefaclor (10mg/ml) showed positive reactions. Bronchial challenge test with cefadroxil showed immediate asthmatic reaction, and bronchial challenge with cefaclor showed immediate urticaria and angioedema without significant fall in FEV1. We confirmed cefadroxil-induced bronchial asthma sensitized by intermittent inhalation in a non-occupational setting.
