Axon Guidance Molecules Guiding Neuroinflammation
- Author:
Won Suk LEE
1
;
Won Ha LEE
;
Yong Chul BAE
;
Kyoungho SUK
Author Information
- Publication Type:Review
- Keywords: Axon guidance molecule; Neuroinflammation; Glia; Neurodegenerative disease
- MeSH: Axons; Ephrins; Inflammation; Nervous System; Neurodegenerative Diseases; Neuroglia; Semaphorins
- From:Experimental Neurobiology 2019;28(3):311-319
- CountryRepublic of Korea
- Language:English
- Abstract: Axon guidance molecules (AGMs), such as Netrins, Semaphorins, and Ephrins, have long been known to regulate axonal growth in the developing nervous system. Interestingly, the chemotactic properties of AGMs are also important in the postnatal period, such as in the regulation of immune and inflammatory responses. In particular, AGMs play pivotal roles in inflammation of the nervous system, by either stimulating or inhibiting inflammatory responses, depending on specific ligand-receptor combinations. Understanding such regulatory functions of AGMs in neuroinflammation may allow finding new molecular targets to treat neurodegenerative diseases, in which neuroinflammation underlies aetiology and progression.
