Association between Circulating Irisin and C-Reactive Protein Levels: A Systematic Review and Meta-Analysis
10.3803/EnM.2019.34.2.140
- Author:
Elham ESLAMPOUR
1
;
Farzad EBRAHIMZADEH
;
Amir ABBASNEZHAD
;
Mohammad Zeinali KHOSROSHAHI
;
Razieh CHOGHAKHORI
;
Omid ASBAGHI
Author Information
1. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. abbasnezhad.a@ajums.ac.ir
- Publication Type:Meta-Analysis
- Keywords:
C-reactive protein;
Irisin;
FNDC5 protein;
Systematic review;
Meta-analysis
- MeSH:
C-Reactive Protein;
Cohort Studies;
Healthy Volunteers;
Overweight;
Population Characteristics;
Sample Size
- From:Endocrinology and Metabolism
2019;34(2):140-149
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Although previous studies have demonstrated that irisin plays an anti-inflammatory role in the body, conflicting results have been reported regarding the correlation between serum levels of irisin and C-reactive protein (CRP). The present meta-analysis was conducted to further investigate the correlation between irisin and CRP levels. METHODS: We systematically searched PubMed, the Cochrane Library, Web of Science, Embase, SCOPUS, and Ovid to retrieve studies assessing the correlation between irisin and CRP levels. Meta-analyses were performed using a random-effects model, and the I 2 index was used to evaluate heterogeneity. RESULTS: Of the 428 studies that were initially found, 14 studies with 2,530 participants met the inclusion criteria for the meta-analysis. The pooled effect size was calculated as 0.052 (95% confidence interval, −0.047 to 0.152; P=0.302). Subgroup analyses identified s ignificant, positive, but weak correlations between CRP and irisin levels in cohort studies, studies conducted among healthy participants, studies in which the male-to-female ratio was less than 1, in overweight or obese subjects, and in studies with a sample size of at least 100 participants. CONCLUSION: The present meta-analysis found no overall significant correlation between irisin and CRP levels, although a significant positive correlation was found in overweight or obese subjects. Well-designed studies are needed to verify the results of the present meta-analysis.
