Postoperative Thyroid-Stimulating Hormone Levels Did Not Affect Recurrence after Thyroid Lobectomy in Patients with Papillary Thyroid Cancer
10.3803/EnM.2019.34.2.150
- Author:
Myung Chul LEE
1
;
Min Joo KIM
;
Hoon Sung CHOI
;
Sun Wook CHO
;
Guk Haeng LEE
;
Young Joo PARK
;
Do Joon PARK
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Thyroid cancer, papillary;
Recurrence;
Thyroid neoplasms;
Thyrotropin
- MeSH:
Follow-Up Studies;
Humans;
Recurrence;
Risk Factors;
Thyroid Gland;
Thyroid Neoplasms;
Thyroidectomy;
Thyrotropin
- From:Endocrinology and Metabolism
2019;34(2):150-157
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Thyroid-stimulating hormone (TSH) suppression is recommended for patients who undergo thyroidectomy for differentiated thyroid cancer (DTC). However, the impact of TSH suppression on clinical outcomes in low-risk DTC remains uncertain. Therefore, we investigated the effects of postoperative TSH levels on recurrence in patients with low-risk DTC after thyroid lobectomy. METHODS: Patients (n=1,528) who underwent thyroid lobectomy for papillary thyroid carcinoma between 2000 and 2012 were included in this study. According to the mean and dominant TSH values during the entire follow-up period or 5 years, patients were divided into four groups (<0.5, 0.5 to 1.9, 2.0 to 4.4, and ≥4.5 mIU/L). Recurrence-free survival was compared among the groups. RESULTS: During the 5.6 years of follow-up, 21 patients (1.4%) experienced recurrence. Mean TSH levels were within the recommended low-normal range (0.5 to 1.9 mIU/L) during the total follow-up period or 5 years in 38.1% or 36.0% of patients. The mean and dominant TSH values did not affect recurrence-free survival. Adjustment for other risk factors did not alter the results. CONCLUSION: Serum TSH levels did not affect short-term recurrence in patients with low-risk DTC after thyroid lobectomy. TSH suppression should be conducted more selectively.
