Triglyceride Glucose Index Is Superior to the Homeostasis Model Assessment of Insulin Resistance for Predicting Nonalcoholic Fatty Liver Disease in Korean Adults
10.3803/EnM.2019.34.2.179
- Author:
Sang Bae LEE
1
;
Min Kyung KIM
;
Shinae KANG
;
Kahui PARK
;
Jung Hye KIM
;
Su Jung BAIK
;
Ji Sun NAM
;
Chul Woo AHN
;
Jong Suk PARK
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. pjs00@yuhs.ac
- Publication Type:Original Article
- Keywords:
Triglyceride glucose index;
Insulin resistance;
Non-alcoholic fatty liver disease
- MeSH:
Adult;
Biomarkers;
Glucose;
Health Promotion;
Homeostasis;
Humans;
Insulin Resistance;
Insulin;
Logistic Models;
Non-alcoholic Fatty Liver Disease;
Odds Ratio;
Prevalence;
Risk Factors;
ROC Curve;
Triglycerides;
Ultrasonography
- From:Endocrinology and Metabolism
2019;34(2):179-186
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance which is a well-known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and NAFLD. Thus, we investigated the relationship between the TyG index and NAFLD and the effectiveness of the TyG index compared with the homeostasis model assessment of insulin resistance (HOMA-IR) in identifying NAFLD in Korean adults. METHODS: Participants of 4,986 who underwent ultrasonography in a health promotion center were enrolled. The TyG index was calculated as ln [fasting triglycerides (mg/dL)×fasting glucose (mg/dL)/2], and HOMA-IR was estimated. NAFLD was diagnosed by ultrasonography. RESULTS: Significant differences were observed in metabolic parameters among the quartiles of the TyG index. The prevalence of NAFLD significantly increased with increment in the TyG index. After adjusting for multiple risk factors, a logistic regression analysis was performed. When the highest and lowest quartiles of the TyG index and HOMA-IR were compared, the odds ratios for the prevalence of NAFLD were 2.94 and 1.93 (95% confidence interval, 2.32 to 3.72 and 1.43 to 2.61; both P for trend <0.01), respectively. According to the receiver operating characteristic analysis, the TyG index was superior to HOMA-IR in predicting NAFLD. CONCLUSION: The TyG index and prevalence of NAFLD were significantly related and the TyG index was superior to HOMA-IR in predicting NAFLD in Korean adults.
