Interferon-gamma Release Assay Using Pericardial Fluid and Peripheral Blood for the Diagnosis of Tuberculous Pericarditis: A Case Report.
- Author:
Kyung Sun PARK
1
;
Hyung Doo PARK
;
Chang Seok KI
;
Nam Yong LEE
;
Sung A CHANG
;
Eun Suk KANG
Author Information
- Publication Type:Case Report
- Keywords: Mycobacterium tuberculosis; Interferon-gamma release assay; Tuberculous pericarditis
- MeSH: Adenosine Deaminase; Diagnosis*; Interferon-gamma Release Tests*; Interferon-gamma*; Mycobacterium tuberculosis; Pericardial Effusion; Pericarditis, Tuberculous*
- From:Laboratory Medicine Online 2014;4(2):116-121
- CountryRepublic of Korea
- Language:Korean
- Abstract: Here, we report a case in which the rapid diagnosis of tuberculous pericarditis was made using Mycobacterium tuberculosis (MTB)-specific interferon-gamma release assay on peripheral blood and pericardial effusion. Acid-fast bacilli staining, mycobacterial culture, and nucleic acid amplification targeting MTB using pericardial fluid were negative. However, elevated adenosine deaminase (ADA) activity in pericardial fluid and interferon-gamma release assay positivity in both pericardial fluid and peripheral blood indicated the presence of tuberculous pericarditis. After anti-tuberculous and steroid treatment, the patient's clinical symptoms improved, and pericardial effusion has not reoccurred.
