Relating Prognosis in Chromophobe Renal Cell Carcinoma to the Chromophobe Tumor Grading System.
10.4111/kju.2014.55.4.239
- Author:
Elizabeth P WEINZIERL
1
;
Alan E THONG
;
Jesse K MCKENNEY
;
Seung Hyun JEON
;
Benjamin I CHUNG
Author Information
1. Department of Pathology, Stanford University Medical Center, Stanford, CA, USA.
- Publication Type:Original Article
- Keywords:
Nephrectomy;
Prognosis;
Renal cell carcinoma
- MeSH:
Carcinoma, Renal Cell*;
Diagnosis;
Follow-Up Studies;
Mortality;
Neoplasm Grading*;
Nephrectomy;
Pathology, Surgical;
Prognosis*;
Recurrence;
Tertiary Care Centers
- From:Korean Journal of Urology
2014;55(4):239-244
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The chromophobe subtype of renal cell carcinoma (chRCC) has generally been associated with a better prognosis than the clear cell type; however, debate continues as to absolute prognosis as well as the significance of certain prognostic variables. We investigated the significance of pathologic stage and a recently proposed chromophobe tumor grading (CTG) scheme in predicting chRCC outcomes. MATERIALS AND METHODS: All available chRCCs were identified from our surgical pathology archives from 1987-2010. Original slides were reviewed to verify diagnoses and stage, and each case was graded following a novel chromophobe tumor grade system criteria. Disease status was obtained from a clinical outcome database, and cancer specific deaths and recurrences were recorded. RESULTS: Eighty-one cases of chRCC were identified, and 73 had adequate follow-up information available. There were only 3 instances of cancer related recurrence or mortality, which included 1 disease specific mortality and 2 disease recurrences. Pathologic stage and CTG 3 were found to be significantly associated with the recurrences or death from chRCC, but there was no association with CTG 1 and CTG 2. CONCLUSIONS: chRCC is associated with a very low rate of cancer specific events (4.1%) even at a tertiary referral center. In our study, pathologic stage and CTG 3, but not CTG 1 or 2, were significantly associated with the development of these events.
