The Impact of Paliperidone Palmitate on Hospitalization in Patients with Schizophrenia: A Retrospective Mirror-image Study
10.9758/cpn.2019.17.4.531
- Author:
So Young OH
1
;
Duk In JON
;
Hyun Ju HONG
;
Narei HONG
;
Jung Seo YI
;
Daeyoung ROH
;
Myung Hun JUNG
Author Information
1. Department of Psychiatry, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. mhjung@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Paliperidone palmitate;
Mirror-image study;
Number of admissions;
Number of bed days;
Sensitivity analyses
- MeSH:
Antipsychotic Agents;
Diagnosis;
Hospitalization;
Humans;
Paliperidone Palmitate;
Psychotic Disorders;
Retrospective Studies;
Schizophrenia
- From:Clinical Psychopharmacology and Neuroscience
2019;17(4):531-536
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Whether long-acting injectable antipsychotics (LAI) are superior to oral antipsychotics remains a controversial question, and results vary depending on the study design. Our study was performed to compare outcomes of oral anti-psychotics and paliperidone palmitate (PP) in clinical practice by investigating the numbers of admissions and bed days. METHODS: We performed a retrospective observational mirror-image study at a single medical center, reviewing medical charts to obtain the clinical data. Forty-six patients with a diagnosis of schizophrenia or schizoaffective disorder who had received at least two doses of PP were included in the analysis. The Wilcoxon signed-rank test was used to compare the numbers of bed days and admissions 1 year before starting PP with those numbers at 1 year after. RESULTS: The mean number of admissions fell from 0.83 to 0.17 per patient (p < 0.0002), and the median fell from 1 to 0. The mean number of bed days decreased significantly, from 24.85 to 8.74 days (p < 0.006). The outcomes remained similar in sensitivity analyses set up with different mirror points. CONCLUSION: Our results indicate that initiating PP reduced the mean numbers of hospital admissions and bed days compared with prior oral medication. LAIs may thus be cost effective in practice; its use bringing about cost reductions greater than its purchase cost.
