Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report
10.9758/cpn.2019.17.4.559
- Author:
Shinichiro OCHI
1
;
Saori INOUE
;
Yuta YOSHINO
;
Hideaki SHIMIZU
;
Jun ichi IGA
;
Shu ichi UENO
Author Information
1. Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Japan. sugekoma80@hotmail.com
- Publication Type:Case Report
- Keywords:
Asenapine;
Treatment-refractory schizophrenia;
Clozapine;
Electroconvulsive therapy;
Suicide;
Recurrence
- MeSH:
Antipsychotic Agents;
Bipolar Disorder;
Clozapine;
Dopamine;
Electroconvulsive Therapy;
Humans;
Recurrence;
Schizophrenia;
Serotonin;
Suicide
- From:Clinical Psychopharmacology and Neuroscience
2019;17(4):559-563
- CountryRepublic of Korea
- Language:English
-
Abstract:
Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails. In this report, a severe treatment-refractory schizophrenic patient who did not respond to clozapine even with ECT, but who recovered with asenapine monotherapy, is presented. Asenapine, considered a serotonin spectrum dopamine modulator, is a new atypical antipsychotic with unique pharmacological features that is used not only for schizophrenia, but also for bipolar disorder. The unique features of asenapine may be effective for some treatment-refractory schizophrenic patients.
