The Effect of Daily Low Dose Tadalafil on Cerebral Perfusion and Cognition in Patients with Erectile Dysfunction and Mild Cognitive Impairment
10.9758/cpn.2019.17.3.432
- Author:
Jin Bong CHOI
1
;
Kang Jun CHO
;
Joon Chul KIM
;
Chung Ho KIM
;
Yong An CHUNG
;
Hyeonseok S JEONG
;
Yong Soo SHIM
;
Jun Sung KOH
Author Information
1. Department of Urology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. gostraight@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Cerebrovascular circulation;
Cognition;
Phosphodiesterase inhibitors
- MeSH:
Brain Stem;
Cerebrovascular Circulation;
Clinical Study;
Cognition;
Dizziness;
Erectile Dysfunction;
Humans;
Male;
Methylenebis(chloroaniline);
Mild Cognitive Impairment;
Myalgia;
Parietal Lobe;
Perfusion;
Phosphodiesterase Inhibitors;
Prospective Studies;
Somatosensory Cortex;
Tadalafil;
Tomography, Emission-Computed
- From:Clinical Psychopharmacology and Neuroscience
2019;17(3):432-437
- CountryRepublic of Korea
-
Abstract:
OBJECTIVE: The aims of this study were to investigate the effects of daily low-dose tadalafil on cognitive function and to examine whether there was a change in cerebral blood flow (CBF) in patients with erectile dysfunction (ED) and mild cognitive impairment. METHODS: Male patients aged 50 to 75 years with at least three months of ED (International Index of Erectile Function [IIEF]-5 score ≤ 21) and mild cognitive impairment (Montreal Cognitive Assessment [MoCA] score ≤ 22) were included in the study. The subjects were prescribed a low-dose PDE5 inhibitor (tadalafil 5 mg) to be taken once daily for eight weeks. Changes in MoCA score and single-photon emission computed tomography (SPECT) study between the two time-points were assessed by paired t tests. RESULTS: Overall, 30 male patients were assigned to the treatment group in this study and 25 patients completed the eight-week treatment course. Five patients were withdrawn due to adverse events such as myalgia and dizziness. Mean baseline IIEF and MoCA scores were 7.52 ± 4.84 and 18.92 ± 1.78. After the eight-week treatment, mean IIEF and MoCA scores were increased to 12.92 ± 7.27 (p < 0.05) and 21.8 ± 1.71 (p < 0.05), respectively. Patients showed increased relative regional CBF in the postcentral gyrus, precuneus, and brainstem after tadalafil administration versus at baseline (p < 0.001). CONCLUSION: The results of this prospective clinical study suggest that daily use of tadalafil 5 mg increases some regional CBF and improves cognitive function in patients with ED and mild cognitive impairment.
