A Case of Acute Myeloid Leukemia with an Unusual Phenotype.
- Author:
Mi Hyang KIM
1
;
Seok Hoon JEONG
Author Information
1. Department of Clinical Pathology, Faculty of Medicine, Kosin University, Pusan, Korea.
- Publication Type:Case Report
- Keywords:
Acute myeloid leukemia;
Myeloperoxidase;
CD13, CD14, CD15, CD33, t (8;
21)
- MeSH:
Cytogenetics;
Flow Cytometry;
HLA-DR Antigens;
Immunoglobulins;
Leukemia;
Leukemia, Myeloid, Acute*;
Peroxidase;
Phenotype*
- From:Korean Journal of Clinical Pathology
1998;18(1):42-45
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We introduce an unusual case of acute myeloid leukemia (AML) showing strong myeloperoxidase (MPO) positivity without any lineage-specific cell surface marker expression, i.e. myelomonocytic antigens CD13, CD14, CD15 and CD33; or B-lymphoid antigens CD10, CD19, CD20, CD22 and surface immunoglobulin; or T-lymphoid antigens CD2, CD3, CD5 and CD7. The case was morphologically AML with maturation (FAB M2) and the cytogenetic study showed t (8; 21) (q22; q22) and missing Y. But Immunophenotypic studies by flow cytometry showed positive reaction ony for CD34 and HLA-DR. We considered this case as a 'presence of t (8; 21) in MPO (+), CD antigen (-) AML'. The myeloid lineage antigens are known to be expressed very early during myeloid differentiation whereas MPO (in its functional form) is viewed as being expressed relatively late in the process. Therefore, this case could be an example of 'asynchronous differentiation' in leukemia.
