Development and surveillance of hepatocellular carcinoma in patients with sustained virologic response after antiviral therapy for chronic hepatitis C
- Author:
Seong Kyun NA
1
;
Byung Cheol SONG
Author Information
- Publication Type:Review
- Keywords: Chronic hepatitis C; Sustained virologic response; Hepatocellular carcinoma
- MeSH: Carcinoma, Hepatocellular; Fibrosis; Genotype; Hepacivirus; Hepatitis C, Chronic; Hepatitis, Chronic; Humans; Incidence; Liver Cirrhosis; Mortality; Risk Factors
- From:Clinical and Molecular Hepatology 2019;25(3):234-244
- CountryRepublic of Korea
- Language:English
- Abstract: Hepatitis C virus (HCV) infection is a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC), and is a leading cause of liver-related deaths worldwide. Recently available direct-acting antiviral agent is very safe and highly effective (>95% sustained virologic response, SVR) against all genotypes of HCV. Achievement of SVR has been associated with a significant reduction of hepatic decompensation, development of HCC, and liver-related mortality. However, HCC risk is not eliminated even after SVR. The annual incidences of HCC in advanced fibrosis or cirrhosis have been estimated to be up to 2.5–4.5% even in patients with SVR. Therefore, surveillance for HCC is recommended in this high-risk patients. In this review, we will describe the clinical outcomes and the risk of HCC in patients with SVR and suggest who should receive surveillance for HCC.
