Effect of simultaneous administration of foot-and-mouth disease (FMD) and anthrax vaccines on antibody response to FMD in sheep
10.7774/cevr.2019.8.2.103
- Author:
Can ÇOKÇALIŞKAN
1
;
Pelin TUNCER GÖKTUNA
;
Tunçer TÜRKOĞLU
;
Ergün UZUNLU
;
Ceylan GÜNDÜZALP
;
Eylem Aras UZUN
;
Beyhan SAREYYÜPOĞLU
;
Ayça KÜRKÇÜ
;
Veli GÜLYAZ
Author Information
1. Republic of Turkey Ministry of Agriculture and Forestry, Institute of Foot and Mouth Disease (SAP), Ankara, Turkey. cancokcaliskan@gmail.com
- Publication Type:Original Article
- Keywords:
Foot-and-mouth disease;
Anthrax;
Simultaneous vaccination;
Sheep;
Virus neutralization
- MeSH:
Animals;
Anthrax Vaccines;
Anthrax;
Antibody Formation;
Cattle;
Enzyme-Linked Immunosorbent Assay;
Foot-and-Mouth Disease;
Neutralization Tests;
Sheep;
Vaccination;
Vaccines
- From:Clinical and Experimental Vaccine Research
2019;8(2):103-109
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Foot-and-mouth disease (FMD) and anthrax are important diseases in sheep. Vaccination is a favorable strategy against both infections. Simultaneous administration of vaccines does generally not impede the immune responses of each other, although there are some exceptions, and it may help reduce the labor and costs of vaccination as well as distress on animals. Although oil adjuvant FMD vaccine has been tried with live anthrax vaccine in cattle, there are no reports on the simultaneous use of both vaccines in sheep. MATERIALS AND METHODS: In this study, FMD seronegative sheep were used to investigate the impact of the simultaneous vaccination of FMD and anthrax on FMD antibody titers of sheep. Virus neutralization test and liquid phase blocking enzyme-linked immunosorbent assay were used to determine the antibody response to the FMD vaccine. RESULTS: The results demonstrated that both vaccines can be used simultaneously without any interference with the FMD response. Moreover, the simultaneous administration with anthrax vaccine had a stimulating effect on the early (day 7 post-vaccination) virus neutralization antibody response to the FMD vaccine. CONCLUSION: The simultaneous use of the FMD and anthrax vaccines did not hinder the response to the FMD vaccine in sheep.
