Understanding the molecular mechanisms of bisphenol A action in spermatozoa
- Author:
Md Saidur RAHMAN
1
;
Myung Geol PANG
Author Information
- Publication Type:Review
- Keywords: Bisphenol A; Endocrine disruptors; Mechanism of action; Oxidative stress; Spermatozoa
- MeSH: Consensus; Endocrine Disruptors; Endocrine System; Humans; Male; Oxidative Stress; Spermatozoa
- From:Clinical and Experimental Reproductive Medicine 2019;46(3):99-106
- CountryRepublic of Korea
- Language:English
- Abstract: Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of interfering with the normal function of the endocrine system in the body. Exposure to this chemical from BPA-containing materials and the environment is associated with deleterious health effects, including male reproductive abnormalities. A search of the literature demonstrated that BPA, as a toxicant, directly affects the cellular oxidative stress response machinery. Because of its hormone-like properties, it can also bind with specific receptors in target cells. Therefore, the tissue-specific effects of BPA mostly depend on its endocrine-disrupting capabilities and the expression of those particular receptors in target cells. Although studies have shown the possible mechanisms of BPA action in various cell types, a clear consensus has yet to be established. In this review, we summarize the mechanisms of BPA action in spermatozoa by compiling existing information in the literature.
