Effects of paternal age on human embryo development in in vitro fertilization with preimplantation genetic screening
10.5653/cerm.2019.46.1.22
- Author:
Min Kyoung KIM
1
;
Jae Kyun PARK
;
Yunmi JEON
;
Su Hee SEOK
;
Eun Mi CHANG
;
Woo Sik LEE
Author Information
1. Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea. wooslee@cha.ac.kr
- Publication Type:Original Article
- Keywords:
Embryo quality;
In vitro fertilization;
Paternal age;
Preimplantation genetic screening
- MeSH:
Aneuploidy;
Blastocyst;
Chromosome Aberrations;
DNA Fragmentation;
Embryonic Development;
Embryonic Structures;
Female;
Fertilization in Vitro;
Genetic Testing;
Germ Cells;
Humans;
In Vitro Techniques;
Maternal Age;
Medical Records;
Paternal Age;
Pregnancy;
Pregnancy Rate;
Sample Size;
Spermatozoa
- From:Clinical and Experimental Reproductive Medicine
2019;46(1):22-29
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: As paternal age increases, the quality of sperm decreases due to increased DNA fragmentation and aneuploidy. Higher levels of structural chromosomal aberrations in the gametes ultimately decrease both the morphologic quality of embryos and the pregnancy rate. In this study, we investigated whether paternal age affected the euploidy rate. METHODS: This study was performed using the medical records of patients who underwent in vitro fertilization (IVF) procedures with preimplantation genetic screening (PGS) from January 2016 to August 2017 at a single center. Based on their morphological grade, embryos were categorized as good- or poor-quality blastocysts. The effects of paternal age were elucidated by adjusting for maternal age. RESULTS: Among the 571 total blastocysts, 219 euploid blastocysts were analyzed by PGS (38.4%). When the study population was divided into four groups according to both maternal and paternal age, significant differences were only noted between groups that differed by maternal age (group 1 vs. 3, p=0.031; group 2 vs. 4, p=0.027). Further analysis revealed no significant differences in the euploidy rate among the groups according to the morphological grade of the embryos. CONCLUSION: Paternal age did not have a significant impact on euploidy rates when PGS was performed. An additional study with a larger sample size is needed to clarify the effects of advanced paternal age on IVF outcomes.
