Therapeutic Effect of Fimasartan in a Rat Model of Myocardial Infarction Evaluated by Cardiac Positron Emission Tomography with ¹⁸FFPTP
10.4068/cmj.2019.55.2.109
- Author:
Hyukjin PARK
1
;
Hyeon Sik KIM
;
Young Joon HONG
;
Jung Joon MIN
;
Han Byul KIM
;
Min Chul KIM
;
Doo Sun SIM
;
Ju Han KIM
;
Dong Yeon KIM
;
Jae Sung LEE
;
Youngkeun AHN
;
Myung Ho JEONG
Author Information
1. Division of Cardiology, Chonnam National University Hospital, Gwangju, Korea. hyj200@hanmail.net jjmin@jnu.ac.kr
- Publication Type:Original Article
- Keywords:
Myocardial Infarction;
Positron Emission Tomography;
Angiotensin Receptor Antagonists
- MeSH:
Angiotensin Receptor Antagonists;
Animals;
Coronary Vessels;
Echocardiography;
Electrons;
Follow-Up Studies;
Infarction;
Ligation;
Models, Animal;
Myocardial Infarction;
Perfusion;
Positron-Emission Tomography;
Rats
- From:Chonnam Medical Journal
2019;55(2):109-115
- CountryRepublic of Korea
- Language:English
-
Abstract:
We evaluated the efficacy of fimasartan on perfusion defects and infarction size in an animal model of myocardial infarction (MI), with echocardiography and positron emission tomography (PET) using a ¹⁸F-labeled phosphonium cation (5-[¹⁸F]-fluoropentyl-triphenylphosphonium salt, [¹⁸F]FPTP) as a mitochondrial voltage sensor for myocardial imaging. We induced MI in 33 rats by ligation of the left coronary artery, and checked their cardiac PET image using [¹⁸F]FPTP for evaluation of myocardial perfusion. Rats were grouped into 3 groups according to their administered drugs: no drug (n=11), fimasartan 3 mg/kg (n=10), and fimasartan 10 mg/kg (n=12). Each designated drug was administered for 4 weeks, and follow-up PET and histologic examinations were done. In the PET analysis, a perfusion defect size was markedly improved in fimasartan 10 mg/kg group (35.9±7.0% to 28.4±6.9%, p<0.001), whereas treatment with fimasartan 3 mg/kg induced only an insignificant reduction of perfusion defect size (35.9±7.9% to 33.9±7.3%, p=0.095). Using 2, 3, 5-triphenyltetrazolium chloride staining, infarction size was the largest in the control group (36.5±8.3%), and was insignificantly lower in the fimasartan 3 mg/kg group (31.5±6.5%, p for the difference between the control group=0.146) and was significantly lower in the fimasartan 10 mg/kg group (26.3±7.6%, p for the difference between the control group=0.011). PET imaging using a ¹⁸F-labeled mitochondrial voltage sensor, [¹⁸F]FPTP, is useful in evaluation and monitoring of myocardial perfusion states, and treatment with fimasartan decreases the infarction size in animal MI model.
