Circulating Permeability Factors in Idiopathic Nephrotic Syndrome
10.3339/jkspn.2019.23.1.7
- Author:
Tae Sun HA
1
Author Information
1. Department of Pediatrics, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea. tsha@chungbuk.ac.kr
- Publication Type:Review
- Keywords:
Nephrotic syndrome;
Permeability Factors;
Proteinuria;
Minimal change disease;
Focal segmental glomerulosclerosis
- MeSH:
Biopsy;
Child;
Edema;
Foot;
Glomerulosclerosis, Focal Segmental;
Humans;
Hyperlipidemias;
Hypoalbuminemia;
Microscopy;
Microscopy, Electron;
Models, Theoretical;
Nephrosis, Lipoid;
Nephrotic Syndrome;
Permeability;
Proteinuria;
Recurrence
- From:Childhood Kidney Diseases
2019;23(1):7-21
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nephrotic syndrome (NS) is a common chronic glomerular disease in children characterized by significant proteinuria with resulting hypoalbuminemia, edema, and hyperlipidemia. Renal biopsy findings of diffuse foot processes effacement on electron microscopy and minimal change disease, focal segmental glomerulosclerosis (FSGS), or diffuse mesangial proliferation on light microscopy. It has been speculated that circulating permeability factors would be implicated in the pathogenesis of NS because they have been reportedly detected in the sera of patients and in experimental models of induced proteinuria. Moreover, a substantial portion of the patients with primary FSGS recurrence shortly after transplantation. This report reviews the current knowledge regarding the role of circulating permeability factors in the pathogenesis of proteinuria in NS and suggests future targeted therapeutic approaches for NS.
