Cognitive Therapy Combined with Drug Treatment in Patients with Alzheimer's Disease: A Neuropsychological and Positron Emission Tomography Investigation, a Pilot Study.
10.12779/dnd.2015.14.2.76
- Author:
Haeri NA
1
;
Sangyun KIM
;
Yu Kyeong KIM
;
Moon Ho PARK
;
Sung Tae CHO
;
Woo Jung KIM
Author Information
1. Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea.
- Publication Type:Case Report
- Keywords:
cognitive therapy;
Alzheimer's disease;
18F-2-fluoro-2-deoxy-D-glucose positron emission tomography
- MeSH:
Alzheimer Disease*;
Behavior Therapy;
Brain;
Cognitive Therapy*;
Exercise;
Humans;
Learning;
Metabolism;
Pilot Projects*;
Positron-Emission Tomography*
- From:Dementia and Neurocognitive Disorders
2015;14(2):76-82
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Cognitive therapy may have therapeutic benefit in patients with early Alzheimer's disease (AD). CASE REPORT: This was a 12-week, single-blind pilot study of 4 patients with AD. The cognitive therapy included exercises for orientation to time and place; memory training, including face-name association, object recall training, and spaced retrieval; visuo-motor organization using software; similarity and ruled based categorization; and behavior modification and sequencing (e.g., making change, paying bills). The regional cerebral metabolic abnormalities and the effects of treatment on cortical metabolic responses were evaluated using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (PET). After 12 weeks, the participants showed slight improvement in some neuropsychological measures, and three of them showed increased regional cortical metabolism on brain PET studies. CONCLUSIONS: Cognitive therapy may stabilize or improve cognitive and functional performance of patients with early AD and increase regional cortical metabolism of the patients' brain.
