Longitudinal Clinical Changes of Non-Fluent/Agrammatic Primary Progressive Aphasia as Tau Spectrum Disorder: A Case Report.
10.12779/dnd.2015.14.2.87
- Author:
Jin Soo KIM
1
;
Jae Won JANG
;
Seong Heon KIM
;
Min Jeong WANG
;
Young Ho PARK
;
Sangyun KIM
Author Information
1. Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea.
- Publication Type:Case Report
- Keywords:
taupathy;
non-fluent/agrammatic primary progressive aphasia;
corticobasal degeneration;
progressive supranuclear palsy
- MeSH:
Aphasia, Primary Progressive*;
Central Nervous System;
Humans;
Phenotype;
Supranuclear Palsy, Progressive;
tau Proteins;
Tauopathies
- From:Dementia and Neurocognitive Disorders
2015;14(2):87-93
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Tauopathies are a group of diseases caused by the accumulation of hyperphosphorylated tau protein in the central nervous system. Previous studies have revealed that there is considerable overlap in clinical, pathological, and genetic features among different taupathies. CASE REPORT: We report a patient with non-fluent/agrammatic primary progressive aphasia at the initial assessment. Over time, other symptoms belonging to corticobasal degeneration and progressive supranuclear palsy appeared in this patient. CONCLUSIONS: Clinical overlapping features in these disorders may represent different phenotypes of a single disease process.
