Characteristics, Prognostic Factors, and Survival of Patients with NK/T-Cell Lymphoma of Non-upper Aerodigestive Tract: A 17-Year Single-Center Experience
- Author:
Ze Long LIU
1
;
Xi Wen BI
;
Xue Wen ZHANG
;
De Xin LEI
;
Pan Pan LIU
;
Hang YANG
;
Yan GAO
;
Yuan Xue JIANG
;
Wen Qi JIANG
;
Yi XIA
Author Information
- Publication Type:Original Article
- Keywords: Extranodal NK-T-Cell Lymphoma; Non-upper aerodigestive tract; Prognostic factors; Survival
- MeSH: Cohort Studies; Humans; L-Lactate Dehydrogenase; Lymphoma; Lymphoma, Extranodal NK-T-Cell; Multivariate Analysis; Population Characteristics; Prognosis
- From:Cancer Research and Treatment 2019;51(4):1557-1567
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The extranodal natural killer (NK)/T-cell lymphoma (NKTCL) of non-upper aerodigestive tract (NUAT) was found to have clinical heterogeneity compared with NKTCL of the upper aerodigestive tract (UAT) in small scale studies. We conducted this study in a much larger cohort to analyze the clinical characteristics, prognostic factors, treatment modality, and clinical outcomes of patients with NUAT-NKTCL. MATERIALS AND METHODS: From January 2001 to December 2017, a total of 757 NKTCL patients were identified and included in this study, including 92 NUAT-NKTCL patients (12.2%) and 665 UAT-NKTCLpatients (87.8%). RESULTS: NUAT-NKTCL patients had relatively poorer performance status, more unfavorable prognostic factors, and more advanced stage, compared with UAT-NKTCL patients. The 5-year overall survival (OS) was 34.7% for NUAT-NKTCL, which was significantly worse than UAT-NKTCL (64.2%, p<0.001). The median OS duration was 30.9 months for NUAT-NKTCL. Multivariate analysis showed that presence with B symptoms and elevated serum lactate dehydrogenase independently predicted worse OS. International prognostic index score and prognostic index of natural killer lymphoma score still had prognostic values in NUAT-NKTCL, while the Ann Arbor system could not accurately predict the OS. CONCLUSION: NUAT-NKTCL is a distinctive subtype of NKTCL in many aspects. Patients with NUAT-NKTCL have relatively poorer performance status, more unfavorable prognostic factors, more advanced stage, and poorer prognosis.
