Clinical Benefit of Maintenance Therapy for Advanced Biliary Tract Cancer Patients Showing No Progression after First-Line Gemcitabine Plus Cisplatin
- Author:
Jaewon HYUNG
1
;
Bumjun KIM
;
Changhoon YOO
;
Kyo Pyo KIM
;
Jae Ho JEONG
;
Heung Moon CHANG
;
Baek Yeol RYOO
Author Information
- Publication Type:Original Article
- Keywords: Biliary tract neoplasms; Gemcitabine; Cisplatin; Cholangiocarcinoma
- MeSH: Biliary Tract Neoplasms; Biliary Tract; Cholangiocarcinoma; Chungcheongnam-do; Cisplatin; Disease-Free Survival; Drug Therapy; Humans; Korea; Retrospective Studies; Seoul
- From:Cancer Research and Treatment 2019;51(3):901-909
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Gemcitabine plus cisplatin (GemCis) is the standard first-line chemotherapy for patients with advanced biliary tract cancer (BTC). In ABC-02 study, the BTC patients received up to 6-8 cycles of 3-weekly GemCis; however, those without progression often receive more than 6-8 cycles. The clinical benefit of maintenance treatment in patients without progression is uncertain. MATERIALS AND METHODS: Advanced BTC patients treated with GemCis between April 2010 and February 2015 at Asan Medical Center, Seoul, Korea, were retrospectively analysed. The patients without progression after 6-8 cycles were stratified according to further treatment i.e., with or without further cycles of GemCis (maintenance vs. observation groups). The primary endpoint was overall survival (OS) and progression-free survival (PFS). RESULTS: Among the 740 BTC patients in the initial screen, 231 cases (31.2%) were eligible for analysis (111 in the observation group, 120 in the maintenance group). The median OS from the GemCis initiation was 20.5 months (95% confidence interval [CI], 15.4 to 25.6) and 22.4 months (95% CI, 17.0 to 27.8) in the observation and maintenance groups, respectively (p=0.162). The median PFS was 10.4 months (95% CI, 7.0 to 13.8) and 13.2 months (95% CI, 11.3 to 15.2), respectively (p=0.320). CONCLUSION: sGemCis maintenance is not associated with an improved survival outcome.
