Prospective Validation of The Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy
- Author:
Jin Won KIM
1
;
Se Hyun KIM
;
Yun Gyoo LEE
;
In Gyu HWANG
;
Jin Young KIM
;
Su Jin KOH
;
Yoon Ho KO
;
Seong Hoon SHIN
;
In Sook WOO
;
Soojung HONG
;
Tae Yong KIM
;
Ji Yeon BAEK
;
Hyun Jung KIM
;
Hyo Jung KIM
;
Myung Ah LEE
;
Jung Hye KWON
;
Yong Sang HONG
;
Hun Mo RYOO
;
Kyung Hee LEE
;
Jee Hyun KIM
Author Information
- Publication Type:Original Article
- Keywords: Geriatric assessment; KG-7; Screening tools; Prospective; Validation
- MeSH: Area Under Curve; Asian Continental Ancestry Group; Drug Therapy; Geriatric Assessment; Humans; Mass Screening; Prospective Studies; Sensitivity and Specificity
- From:Cancer Research and Treatment 2019;51(3):1249-1256
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The purpose of this study was to prospectively validate the Korean Cancer Study Group Geriatric Score (KG)-7, a novel geriatric screening tool, in older patients with advanced cancer planned to undergo first-line palliative chemotherapy. MATERIALS AND METHODS: Participants answered the KG-7 questionnaire before undergoing geriatric assessment (GA) and first-line palliative chemotherapy. The performance of KG-7 was evaluated by calculating the sensitivity (SE), specificity (SP), positive and negative predictive value (PPV and NPV), balanced accuracy (BA), and area under the curve (AUC). RESULTS: The baseline GA and KG-7 results were collected from 301 patients. The median age was 75 years (range, 70 to 93 years). Abnormal GA was documented in 222 patients (73.8%). Based on the ≤ 5 cut-off value of KG-7 for abnormal GA, abnormal KG-7 score was shown in 200 patients (66.4%). KG-7 showed SE, SP, PPV, NPV, and BA of 75.7%, 59.7%, 84.4%, 46.0%, and 67.7%, respectively; AUC was 0.745 (95% confidence interval, 0.687 to 0.803). Furthermore, patients with higher KG-7 scores showed significantly longer survival (p=0.006). CONCLUSION: KG-7 appears to be adequate in identifying patients with abnormal GA prospectively. Hence, KG-7 can be a useful screening tool for Asian countries with limited resources and high patient volume.
