Albumin-to-Fibrinogen Ratio as an Independent Prognostic Parameter in Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of 191 Cases
- Author:
Yi Xin ZOU
1
;
Jia QIAO
;
Hua Yuan ZHU
;
Rui Nan LU
;
Yi XIA
;
Lei CAO
;
Wei WU
;
Hui JIN
;
Wen Jie LIU
;
Jin Hua LIANG
;
Jia Zhu WU
;
Li WANG
;
Lei FAN
;
Wei XU
;
Jian Yong LI
Author Information
- Publication Type:Original Article
- Keywords: Serum albumin; Fibrinogen; B-cell chronic lymphocytic leukemia; Prognosis
- MeSH: B-Lymphocytes; Diagnosis; Fibrinogen; Humans; Inflammation; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoproliferative Disorders; Multivariate Analysis; Prognosis; Retrospective Studies; Serum Albumin
- From:Cancer Research and Treatment 2019;51(2):664-671
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients. MATERIALS AND METHODS: In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients. RESULTS: The cut-off value of AFR was 9.7 calculated by X-tile. Patients who were more than 65 years old were often accompanied by low level of AFR (p < 0.001). Survival analysis showed that patients with low level of AFR had shorter overall survival (OS) than patients with high level of AFR (p < 0.001). Multivariate analysis illustrated that AFR had a negative impact on OS (p=0.003) and was independent of parameters involved in CLL international prognostic index and other prognostic markers such as CD38 and ZAP-70. CONCLUSION: These data provide a comprehensive view of AFR and shows that AFR at diagnosis is an adverse prognostic factor in untreated CLL patients.
