The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade III Cerebral Gliomas in Adults: Version 2019.01
- Author:
Young Zoon KIM
1
;
Chae Yong KIM
;
Jaejoon LIM
;
Kyoung Su SUNG
;
Jihae LEE
;
Hyuk Jin OH
;
Seok Gu KANG
;
Shin Hyuk KANG
;
Doo Sik KONG
;
Sung Hwan KIM
;
Se Hyuk KIM
;
Se Hoon KIM
;
Yu Jung KIM
;
Eui Hyun KIM
;
In Ah KIM
;
Ho Sung KIM
;
Tae Hoon ROH
;
Jae Sung PARK
;
Hyun Jin PARK
;
Sang Woo SONG
;
Seung Ho YANG
;
Wan Soo YOON
;
Hong In YOON
;
Soon Tae LEE
;
Sea Won LEE
;
Youn Soo LEE
;
Chan Woo WEE
;
Jong Hee CHANG
;
Tae Young JUNG
;
Hye Lim JUNG
;
Jae Ho CHO
;
Seung Hong CHOI
;
Hyoung Soo CHOI
;
Je Beom HONG
;
Do Hoon LIM
;
Dong Sup CHUNG
;
Author Information
- Publication Type:Original Article
- Keywords: Korean Society for Neuro Oncology; Guideline; Grade III Gliomas; Practice
- MeSH: Adult; Astrocytoma; Brain; Brain Neoplasms; Central Nervous System; Drug Therapy; Drug Therapy, Combination; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Korea; Lomustine; Oligodendroglioma; Radiotherapy; World Health Organization
- From:Brain Tumor Research and Treatment 2019;7(2):63-73
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: There was no practical guideline for the management of patients with central nervous system tumor in Korea in the past. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, developed the guideline for glioblastoma successfully and published it in Brain Tumor Research and Treatment, the official journal of KSNO, in April 2019. Recently, the KSNO guideline for World Health Organization (WHO) grade III cerebral glioma in adults has been established. METHODS: The Working Group was composed of 35 multidisciplinary medical experts in Korea. References were identified by searches in PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL databases using specific and sensitive keywords as well as combinations of keywords. Scope of the disease was confined to cerebral anaplastic astrocytoma and oligodendroglioma in adults. RESULTS: Whenever radiological feature suggests high grade glioma, maximal safe resection if feasible is globally recommended. After molecular and histological examinations, patients with anaplastic astrocytoma, isocitrate dehydrogenase (IDH)-mutant should be primary treated by standard brain radiotherapy and adjuvant temozolomide chemotherapy whereas those with anaplastic astrocytoma, NOS, and anaplastic astrocytoma, IDH-wildtype should be treated following the protocol for glioblastomas. In terms of anaplastic oligodendroglioma, IDH-mutant and 1p19q-codeletion, and anaplastic oligodendroglioma, NOS should be primary treated by standard brain radiotherapy and neoadjuvant or adjuvant PCV (procarbazine, lomustine, and vincristine) combination chemotherapy. CONCLUSION: The KSNO's guideline recommends that WHO grade III cerebral glioma of adults should be treated by maximal safe resection if feasible, followed by radiotherapy and/or chemotherapy according to molecular and histological features of tumors.
