Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
10.4062/biomolther.2019.061
- Author:
Ao Xuan ZHEN
1
;
Mei Jing PIAO
;
Kyoung Ah KANG
;
Pincha Devage Sameera MADUSHAN FERNANDO
;
Hee Kyoung KANG
;
Young Sang KOH
;
Joo Mi YI
;
Jin Won HYUN
Author Information
1. Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju 63243, Republic of Korea. jinwonh@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
Niacinamide;
Particulate matter 2.5;
Oxidative stress;
Human HaCaT keratinocyte
- MeSH:
Antioxidants;
Apoptosis;
Cell Membrane;
DNA;
Humans;
Keratinocytes;
Mitochondrial Proteins;
Niacinamide;
Oxidative Stress;
Particulate Matter;
Reactive Oxygen Species;
Skin Diseases;
Skin;
Vitamins
- From:Biomolecules & Therapeutics
2019;27(6):562-569
- CountryRepublic of Korea
- Language:English
-
Abstract:
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM(2.5)) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and protein, mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM(2.5)-induced oxidative stress in human HaCaT keratinocytes. We found that NIA could inhibit the ROS generation induced by PM(2.5), as well block the PM(2.5)-induced oxidation of molecules, such as lipids, proteins, and DNA. Furthermore, NIA alleviated PM(2.5)-induced accumulation of cellular Ca²⁺, which caused cell membrane depolarization and apoptosis, and reduced the number of apoptotic cells. Collectively, the findings show that NIA can protect keratinocytes from PM(2.5)-induced oxidative stress and cell damage.
